Scientists managed to turn back development of Alzheimers disease
The staff of Yale university managed to synthesize a preparation which turned back Alzheimer’s disease development in an organism of a laboratory mouse.
Alzheimer’s disease is the neurodegenerate disease more often meeting at people 65 years are more senior. Exists as well a rare form of an illness which develops at earlier age. As of 2006 in the world more than 26 million people suffering from this illness were.
It is possible to refer disorder of short-term memory to early symptoms of an illness, and then long-term memory comes to worthlessness also. Gradual loss of functions of an organism leads over time to death of the patient. Average life expectancy after establishment of the diagnosis makes about 7 years.
Now there is no effective way to cure this disease. Modern methods of therapy are capable to soften some illness symptoms, but unable neither to slow down, nor to stop its development. The largest world pharmaceutical concerns try to create decades means for fight against Alzheimer’s disease but while at them left nothing, and the most part of development was stopped.
Scientists from Yale university created the new medicinal connection, capable to liquidate an Alzheimer’s disease consequence in an organism of a laboratory mouse. Opening happened during studying of special protein in a brain which STEP (STtriatal-Enriched tyrosine Phosphatase) in abbreviated form is called and is responsible for regulation of processes of training and memory. High level of this protein prevents tension синапсов in a brain, and strengthening it is necessary during the moment when short-term memoirs will be transformed to long-term memory.
Having touched thousands various options, scientists managed to find special connection of TC-2153 by means of which it is possible to minimize negative effect of STEP protein on a brain. Applying connection on the brain struck with Alzheimer’s disease, researchers noticed that there was a turn of deficiency of mental capacities of a mouse in a number of cognitive exercises. Among other things, the laboratory mouse started to remember better objects which she saw earlier.
«One dose of a preparation leads to improvement of cognitive functions at mice, – the professor of Yale university Paul Lombrozo shares with readers of the PLOS Biology magazine. – The rodents who have received treatment by a new preparation, were absolutely indistinguishable from the control group consisting of healthy mice».
At present scientists started researches over rats and primacies with cognitive frustration. If it will appear that the preparation is effective and on their organism, is not excluded that tests in public will begin in two-three years.